A list of email addresses you have removed from your regular mailing lists, either because they have opted out of your lists or because they have notified other mailers that they do not want to receive mailings from your company. Required by CAN-SPAM. AKA Do-Not-Email list.

The 3 Things To Avoid When Emailing Your List
When you decide to have an opt-in list, it is not just a matter of sending your subscribers your promotional newsletters or catalogs.