An anti-spam program that requires a human being on the sender’s end to respond to an emailed challenge message before their messages can be delivered to recipients. Senders who answer the challenge successfully are added to an authorization list. Bulk emailers can work with challenge-response if they designate an employee to watch the sending address’ mailbox and to reply to each challenge by hand.

Building an Opt-In List, Building Relationships
If you aim for success, you must do everything within your means to achieve that. You just donÃt go on sitting there in your house complaining about not getting as much profit as you expect.